hrp0082lbp-d3-1015 | (1) | ESPE2014

A Secular Trend for Pubertal Timing in Swedish Men Born 1946–1991: The BEST Cohort

Bygdell Maria , Vandenput Liesbeth , Ohlsson Claes , Kindblom Jenny M

Background: A secular trend for the timing of menarche has been described in women, but for men, studies of pubertal timing are scarce. Both negative and positive associations between childhood obesity and pubertal timing in men have been reported. In Sweden, Child Health Care (CHC) centers follow all children regarding growth and general health. We have collected detailed CHC growth data (height and weight) from centrally archived records for all children born 1946 or later i...

hrp0084p2-232 | Bone | ESPE2015

Regulation of Bone Growth Via Ligand-Specific Activation of Oestrogen Receptor α

Iravani Maryam , Lagerquist Marie , Ohlsson Claes , Savendahl Lars

Background: Oestrogens are well known for their capacity to promote bone maturation and at high doses to induce growth plate closure and thereby stop further growth. High-dose oestrogen treatment has therefore been used to limit growth in extremely tall girls. However, recent data suggest that this treatment may have severe side effects, including increased risk of cancer and reduced fertility.Objective and hypotheses: We hypothesised that oestrogenic ef...

hrp0086fc4.6 | Pathophysiology of Obesity | ESPE2016

The Rise and Fall of the Swedish Childhood Obesity Epidemic – The BEST Cohort

Bygdell Maria , Ohlsson Claes , Celind Jimmy , Saternus Jakob , Sonden Arvid , Kindblom Jenny

Background: Childhood obesity increases the risk for adult obesity and cardio metabolic disease.Objective and hypotheses: The aim with the present study was to investigate longitudinal changes of childhood body mass index (BMI), overweight, and obesity in boys born 1946 until present time, using the population-based BMI Epidemiology STudy (BEST) cohort in Gothenburg, Sweden.Method: We collected detailed growth data (height and weig...